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Journal Club series presented by CGA-IGC
Hereditary or Not?
Category: Education
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by CGA-IGC
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October 19, 2020 08:00 AM PDT

The fifth episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Sir John Burn, who is a professor of clinical genetics at Newcastle University, and Dr. Toni Seppälä, who is a GI surgeon from University of Helsinki currently conducting a research fellowship at Johns Hopkins University. They discuss recently updated data from the CAPP2 study of aspirin chemoprevention in individuals with Lynch syndrome that was published in Lancet this summer, found here: https://pubmed.ncbi.nlm.nih.gov/32534647/.

This episode was recorded on September 22, 2020, and reflects expert opinion at the time of the recording.

September 14, 2020 11:37 AM PDT

This episode is hosted by Dr. Leah Biller and features Dr. Zsofia Stadler, a medical oncologist at Memorial Sloan Kettering Cancer Center and CGA council member, and Dr. Michael Hall, a medical oncologist at Fox Chase Cancer Center and CGA past president. They discuss data from Abstract 1500 (https://meetinglibrary.asco.org/record/185963/abstract), which reports on targeted therapy based on germline analysis of tumor-normal sequencing in a pan-cancer population, as well as data from the plenary presentation about the clinical trial KEYNOTE-177 (https://meetinglibrary.asco.org/record/186928/abstract), a study of pembrolizumab versus standard therapy for treatment of MSI-H metastatic colorectal cancer.

This episode was recorded on August 28, 2020 and reflects expert opinion at the time of the recording.

July 13, 2020 08:44 AM PDT

The third episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Dr. Arne Bleijenberg, who is a research fellow at Amsterdam University Medical Center, and Dr. Evelien Dekker, who is a professor in the Department of Gastroenterology & Hepatology and Gastrointestinal Oncology and the head of the Hereditary Cancer Center at the Amsterdam University Medical Center. They discuss the recently updated World Health Organization Guidelines on diagnosis of Serrated Polyposis Syndrome (SPS) (summarized here https://pubmed.ncbi.nlm.nih.gov/31982410/). Dr. Bleijenberg and Dr. Dekker also discuss their recent publications that shed light on a personalized approach to surveillance in SPS (https://pubmed.ncbi.nlm.nih.gov/30981990/) and long-term outcomes and natural disease course in those with SPS undergoing colonoscopic surveillance (https://pubmed.ncbi.nlm.nih.gov/32360902/). This episode was recorded on July 9, 2020 and reflects expert opinion at the time of the recording.

May 17, 2020 06:59 PM PDT

The second episode features Dr. Leah Biller, CGA education committee member, who is interviewed by fellow CGA education committee member TJ Slavin. They discuss "A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors", recently published online in Cancer Prevention Research. You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32051178
This episode was recorded May 5, 2020 and reflects expert opinion at the time of the recording.

April 13, 2020 10:11 AM PDT

Each episode of the 2020 season of the CGA-IGC podcast series will be a short journal club featuring a recently published article of interest to our membership.

The first episode features Brandie Heald Leach, former CGA president, who is interviewed by CGA education committee member TJ Slavin. They discuss the CGA-IGC position statement on multi-gene panel testing for hereditary colorectal cancer and polyposis, published online in Familial Cancer on March 14, 2020.

You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32172433

This episode was recorded April 8, 2020 and reflects expert opinion at the time of the recording.

December 19, 2019 02:01 PM PST

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.

The sixth and final episode features Kristin Zajo, a genetic counselor at Nationwide Children’s Hospital in Columbus Ohio. In this episode, we focus on children and young adults with FAP and special considerations regarding management and transitioning from pediatric to adult care.

Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

October 22, 2019 03:02 PM PDT

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.

The fifth episode features Dr. Jennifer Sipos, an endocrinologist at the Ohio State University. In this episode, she reviews the epidemiology, surveillance, and management of thyroid disease in FAP.

Note: This episode was recorded on April 26, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Episodes to come in Season 2:
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

September 09, 2019 11:26 AM PDT

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.

The fourth episode features Dr. James Church, colorectal surgeon, and Dr. Dale Shepard, medical oncologist, both of the Cleveland Clinic. In this episode, they discuss the biology, medical and surgical management of desmoid disease in FAP.

Note: This episode was recorded on August 15, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Episodes to come in Season 2:
- "Thyroid Lesion Management" with Jennifer Sipos, MD
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

August 06, 2019 09:04 AM PDT

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.

The third episode features Dr. Jewel Samadder, gastroenterologist and advanced endoscopist at the Mayo Clinic in Phoenix, Arizona. Dr. Samadder has a specific focus on hereditary cancer conditions, with distinct expertise in familial adenomatous polyposis. In this episode, Dr. Samadder discusses the necessary screening, endoscopic and surgical approaches, and chemoprevention options for duodenal neoplasia in FAP.

Note: This episode was recorded on July 16th, 2019 and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Episodes to come in Season 2:
- "Desmoids" with Dr. James Church and Dr. Dale Shepard
- "Thyroid Lesion Management" with Dr. Jennifer Sipos
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

May 28, 2019 01:04 PM PDT

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of APC-Associated conditions.

In the second episode, Dr. Daniel Worthley, an expert in hereditary cancer syndromes from the South Australian Health and Medical Research Institute, tells the tale of how Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) was first recognized and characterized. GAPPS is caused by a mutation in the promotor region of the APC gene and is inherited in an autosomal dominant fashion. This condition is associated with a significantly increased risk of gastric cancer, but unlike FAP, GAPPS is not associated with tumors in the colon or small bowel. Dr. Worthley reviews the characteristics of this rare condition and current approach to management.

Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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